ZDHHC3 is a palmitoyltransferase with broad specificity. ZDHHC3 palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. ZDHHC3 palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi.