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OM262588
Discount Price
OM262588-100ul
1~2 Week
100ul
OM262588-50ul
50ul
OM262588-20ul
20ul
1~2 Week
Product Profile
Product Name MC1R antibody
Antibody Type Primary Antibodies
Product description Rabbit Polyclonal to Human Melanocortin 1 Receptor ( MC1R )MC1R, a Melanocortin Receptor, mediates the effects of melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). MSH and its receptor, MC1R, are key regulators of melanogenesis. They control the relative proportions of red pheomelanin and black photoprotective eumelanin in the skin by increasing the production of eumelanin. Non-functional, truncated forms of the receptor lead to lighter coat color in animals. In contrast, constitutively active receptors lead to darker color. Pheomelanin generates free radicals in response to UV radiation, and elevated levels of pheomelanin have been associated with higher risk of UV-induced skin damage. Therefore, MC1R is a major determinant of sun sensitivity and genetic risk for melanoma and other skin cancers. Expression of melanocortin 1 receptor has been reported primarily in adrenal, skin, and testis. ESTs have been isolated from breast, placenta, and testis libraries.
Immunogen Synthetic peptide - KLH conjugated
Key Feature
Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications IHC-P
Immunohistochemistry with formalin fixed paraffin embedded tissues. Not tested for other uses. IHC-P: Use at a dilution of 1/100 - 1/200.:
Species Reactivity Human
Concentration 1mg/ml (Please refer to the vial label for the specific concentration)
Purification Affinity purified
Target Information
Gene Synonyms CMM5
MGC14337
MSH-R
SHEP2
MSH R
MSHR
Target MC1R
Application Notes Immunohistochemistry with formalin fixed paraffin embedded tissues. Not tested for other uses. IHC-P: Use at a dilution of 1/100 - 1/200.:
Additional Information
Form Liquid
Storage Instructions Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Storage Buffer Phosphate buffered saline, pH 7.4 containing 0.01% sodium azide
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