MAP kinase p38 alpha, a MAPK type protein kinase, is an environmental stress- and inflammatory cytokine-induced kinase that is associated with the regulation of gene expression, cell proliferation and cell death. p38alpha is phosphorylated by MEK3/MAP2K3 or MKK6/MAP2K6. Activated p38alpha either remains in the cytosol, where it phosphorylates cytosolic proteins including MNK1/2, PLA2 and PRAK, or translocates to the nucleus, where it phosphorylates several substrates, including ATF2, CHOP/GADD153, MAPKAPK-2 and -3, MEF2-A and -C, MSK, Myc binding partner Max and Sap-1a. At least four protein isoforms, resulting from alternatively spliced transcript variants of this gene, have been identified - 297, 307 and two isoforms of 360 amino acids with differing internal segments.
Immunogen
MAPK14 antibody was raised against a peptide located in the C Terminus of MAPK14 (Mouse).
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHCWB
MAPK14 antibody can be used in ELISA, Western Blot starting at 1:1000 - 1:2000, and immunohistochemistry starting at 10 μg/mL.