ELL was shown to encode a previously uncharacterized elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. Functionally, ELL resembles Elongin (SIII), a transcription elongation factor regulated by the product of the von Hippel-Lindau (VHL) tumor suppressor gene.1) Wiederschain, D., (2003) Mol. Cell. Biol. 23 (12), 4230-4246.
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ELL.
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
ELISAIHCWB
ELL antibody can be used for detection of ELL by ELISA at 1:1562500. ELL antibody can be used for detection of ELL by western blot at 7.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.:
Antibody used in WB on Transfected 293T at 7.5 ug/ml.
Application
Antibody used in IHC on Human Muscle.
Positive Control
1) Tranfected 293T Cell Lysate
Application Notes
ELL antibody can be used for detection of ELL by ELISA at 1:1562500. ELL antibody can be used for detection of ELL by western blot at 7.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.:
Additional Information
Form
Liquid
Storage Instructions
For short periods of storage (days) store at 4˚C. For longer periods of storage, store ELL antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Storage Buffer
IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.
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