L-Myc Antibody (C-20)

Product Profile

Product Name	L-Myc Antibody (C-20)
Antibody Type	Tags Antibodies
Modification Notes	The v-Myc oncogene, initially identified in the MC29 avian retrovirus, causes myelocytomas, carcinomas, sarcomas and lymphomas, and belongs to a family of oncogenes conserved throughout evolution. In humans, the family consists of five genes: c-Myc, N-Myc, R-Myc, L-Myc and B-Myc. Amplification of the N-Myc gene has been found in human neuroblastomas and cell lines. The extent of N-Myc amplification correlates well with the stage of neuroblastoma disease. Immunological studies have shown that the human N-Myc gene encodes a nuclear phosphoprotein that exhibits relatively short (30 minute) half life in vivo. The prototype member of the family, c-Myc p67, binds DNA in a sequence-specific manner subsequent to dimerization with a second basic region helix-loop-helix leucine zipper motif protein, designated Max.

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Applications	WBIPIFELISA
	recommended for detection of L-Myc of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine:
Species Reactivity	HumanMouseRat
Concentration	1mg/ml
Purification	Affinity purified

Target Information

Alternative Names	epitope mapping within the C-terminus of L-Myc of human origin
Tissue Specificity	epitope mapping within the C-terminus of L-Myc of human origin

Database Links

Entrez Gene	4610

Application

Application Notes	recommended for detection of L-Myc of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine:

Additional Information

Form	Liquid
Storage Instructions	For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer	phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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