MAdCAM-1

Catalog Number：OM641573

  • Fig1: Western blot analysis of MAdCAM-1 expression in ECV304 whole cell lysate.

  • Fig2: Western blot analysis of MAdCAM-1 expression in non-transfected (A) and mouse MAdCAM-1 transfected (B) 293T whole cell lysates.

Product Profile

Product Name MAdCAM-1
Antibody Type Primary Antibodies
Product description 
The recirculation of lymphocytes through different organs is thought to be regulated by adhesion molecules (“homing receptors”) recognizing tissue-specific vascular addressins on the endothelium. The mucosal vascular addressin, MadCAM-1 (mucosal addressin cell adhesion molecule 1), is an immunoglobulin superfamily adhesion molecule for lymphocytes that is expressed by mucosal venules and helps direct lymphocyte traffic into Peyer’s patches and the intestinal lamina propria. MadCAM-1 acts as an endothelial cell ligand for leukocyte homing receptors L-Selectin and Integrin α4/β7. MadCAM-1 is strongly expressed on inflamed portal vein/sinusoidal endothelium in autoimmune-mediated liver disease and plays a major contributory role in the progression of chronic experimental autoimmune encephalomyelitis.
Immunogen 
Endothelial cells from BALB/c mouse mesenteric and peripheral lymph nodes.

Key Feature

Clonality Monoclonal
Isotype IgG2a
Host Species Rat
Tested Applications

FCIFIPWB
WB:1:100-1:1,000
IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
IF:1:50-1:500
FC:1 μg per 1 x 106 cells
Species Reactivity

HumanMouseRat
Concentration 1 mg/ml.
Purification Affinity purified

Target Information

Alternative Names
Addressin mucosal antibody hMAdCAM 1 antibody hMAdCAM-1 antibody MACAM1 antibody MADCA_HUMAN antibody MAdCAM 1 antibody MAdCAM-1 antibody Madcam1 antibody Mucosal addressin cell adhesion molecule 1 antibody
Molecular Weight(MW) 40/29 kDa
Cellular Localization Membrane

Database Links

SwissProt ID Q13477

Application

  • Western blot

    Fig1: Western blot analysis of MAdCAM-1 expression in ECV304 whole cell lysate.

  • Western blot

    Fig2: Western blot analysis of MAdCAM-1 expression in non-transfected (A) and mouse MAdCAM-1 transfected (B) 293T whole cell lysates.

Positive Control ECV304, 293T.
Application Notes
WB:1:100-1:1,000
IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
IF:1:50-1:500
FC:1 μg per 1 x 106 cells

Additional Information

Form Liquid
Storage Instructions Store at +4℃.
Storage Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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  • Catalog Number: OM641573
  • Price: $336.00
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