The v-Myc oncogene, initially identified in the MC29 avian retrovirus, causes myelocytomas, carcinomas, sarcomas and lymphomas (1), and belongs to a family of oncogenes conserved throughout evolution. In humans, the family consists of five genes: c-Myc, N-Myc, R-Myc, L-Myc and B-Myc (2). Amplification of the N-Myc gene has been found in human neuroblastomas and cell lines (3,5). The extent of N-Myc amplification correlates well with the stage of neuroblastoma disease (4). Immunological studies have shown that the human N-Myc gene encodes a nuclear phosphoprotein (2) that exhibits relatively short (30 min) half life in vivo. The prototype member of the family, c-Myc p67, binds DNA in a sequence-specific manner subsequent to dimerization with a second basic region helix-loop-helix leucine zipper motif protein, designated Max (5-7).
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of N-Myc of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian:
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope mapping within the C-terminus of N-Myc of human origin
Tissue Specificity
epitope mapping within the C-terminus of N-Myc of human origin
Western blot analysis of N-Myc expression in non-transfected: (A) and mouse N-Myc transfected: (B) 293T whole cell lysates.
Application Notes
recommended for detection of N-Myc of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian:
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
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