All products Antibodies Rabbit anti-MYC polyclonal antibody - N-terminal region

Rabbit anti-MYC polyclonal antibody - N-terminal region

Catalog Number:OM105970

  • 0.0625ug/ml
    Positive Control: Transfected 293T

Product Profile

Product Name Rabbit anti-MYC polyclonal antibody - N-terminal region
Antibody Type Tags Antibodies
Immunogen
The immunogen for anti-MYC antibody: synthetic peptide directed towards the N terminal of human MYC

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WBIHC

Species Reactivity

BovineDogGuinea PigHumanMousePigRabbitRatSheep

Concentration 1 mg/ml
Purification Affinity purified

Target Information

Gene Symbol MYC
Gene Synonyms
c-Myc
MRTL
bHLHe39
Gene Full Name V-myc myelocytomatosis viral oncogene homolog (avian)
Gene Summary
MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this MYC gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma.The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
Alternative Names
c-Myc
MRTL
bHLHe39
Molecular Weight(MW) 50kDa
Sequence 454 amino acids

Database Links

Entrez Gene 4609
SwissProt ID P01106
Protein Accession NP_002458

Application

  • Immunohistochemical

  • Western blot

    0.0625ug/ml
    Positive Control: Transfected 293T

Additional Information

Form Liquid
Storage Instructions Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles
Storage Buffer phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

  • Catalog Number: OM105970
  • Price: $336.00
  • Discount Price
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  • Store: In stock
  • Lead time: 2~3 Week
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