TRAF1 Antibody (G-20)

Product Profile

Product Name	TRAF1 Antibody (G-20)
Antibody Type	Primary Antibodies
Modification Notes	Tumor necrosis factor (TNF)-activated cell signaling is mediated primarily through the TNF receptor 1 (TNF-R1) and, to a lesser extent, TNF-R2. Both TNF receptors are members of the expanding TNF receptor superfamily which includes the FAS antigen and CD40. Potential insight into an understanding of TNF receptor-mediated signaling was provided by the identification of two related proteins, TRAF1 and TRAF2 (for TNF receptor-associated factors 1 and 2, respectively). Both function to form heterodimeric complexes and associate with the cytoplasmic domain of TNF-R2. A third member of this protein family, alternatively designated CD40 bp, CRAF1, LAP1 or TRAF3, has been identified and shown to associate with the cytoplasmic domain of CD40. The similarity between a specific region of TRAF3 with regions of TRAF1 and TRAF2 define a “TRAF-C” domain that is necessary and sufficient for CD40 binding and homodimerization.

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Applications	WBIPIFFCELISA
	recommended for detection of TRAF1 of human origin by WB, IP, IF, FCM and ELISA; also reactive with additional species, including equine, canine, bovine and porcine:
Species Reactivity	HumanMouseRat
Concentration	1mg/ml
Purification	Affinity purified

Target Information

Alternative Names	epitope mapping at the N-terminus of TRAF1 of human origin
Tissue Specificity	epitope mapping at the N-terminus of TRAF1 of human origin

Database Links

Entrez Gene	7185

Application

Application Notes	recommended for detection of TRAF1 of human origin by WB, IP, IF, FCM and ELISA; also reactive with additional species, including equine, canine, bovine and porcine:

Additional Information

Form	Liquid
Storage Instructions	For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer	phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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• Data sheet for OM154397