All products Antibodies caspase-1 Antibody (A-19) FITC

caspase-1 Antibody (A-19) FITC

Catalog Number:OM159056

  • Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

  • Intracellular FCM analysis of fixed and permeabilized Jurkat cells. Black line histogram represents the isotype control, normal rabbit IgG: .

  • Antibodies tested include caspase-1 p10 (C-20): (A-E) and caspase-1 (A-19): (F-J).

Product Profile

Product Name caspase-1 Antibody (A-19) FITC
Antibody Type Primary Antibodies
Modification Notes Caspase-1, originally designated ICE (for IL-1 converting enzyme), is a member of the group of caspases with large prodomains. Caspase-1 promotes maturation of interleukin IL-1∫ and interleukin18 (IL-18) by proteolytic cleavage of precursor forms into biologically active pro-inflamatory cytokines. Active caspase-1, a (p20/p10)2 tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. The highly conserved family of caspases mediate many of the morphological and biochemical features of apoptosis, including structural dismantling of cell bodies and nuclei, fragmentation of genomic DNA, destruction of regulatory proteins and propagation of other pro-apoptotic molecules. The human Caspase-1 gene maps to chromosome 2q14 and encodes a cytoplasmic protein expressed in liver, heart, skeletal muscle kidney and testis. Caspase-1 has been implicated in inflammation, septic shock, and other situations such as wound healing and the growth of certain leukemias.

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WBIPIFFCELISA

recommended for detection of the caspase-1 precursor, CARD 17, and COP of human origin by WB, IP, IF, FCM and ELISA; non cross-reactive with caspase-1 p10 or caspase-1 p20:
Species Reactivity

HumanMouseRat

Concentration 1mg/ml
Purification Affinity purified

Target Information

Alternative Names
epitope mapping at the N-terminus of caspase-1 of human origin
Tissue Specificity epitope mapping at the N-terminus of caspase-1 of human origin

Database Links

Entrez Gene 834

Application

  • Application

    Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

  • Application

    Intracellular FCM analysis of fixed and permeabilized Jurkat cells. Black line histogram represents the isotype control, normal rabbit IgG: .

  • Application

    Antibodies tested include caspase-1 p10 (C-20): (A-E) and caspase-1 (A-19): (F-J).

Application Notes
recommended for detection of the caspase-1 precursor, CARD 17, and COP of human origin by WB, IP, IF, FCM and ELISA; non cross-reactive with caspase-1 p10 or caspase-1 p20:

Additional Information

Form Liquid
Storage Instructions For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

  • Catalog Number: OM159056
  • Price: $336.00
  • Discount Price
  • Size:
  • Store: Out of stock
  • Lead time: 4~6 Week
  • Quantity:
    - +
  • Shipping to (Please select)
Search the catalog number from any major antibody supplier/brand in the search bar above. The search engine will return OmnimAbs products for these targets.

2013 © Omnimabs , All Rights Reserved.