All products Antibodies p-c-Myc Antibody (Thr 358)

p-c-Myc Antibody (Thr 358)

Catalog Number:OM197728

  • Western blot analysis of phosphorylated c-Myc expression in untreated (A) and UV-treated (B) HT-29 whole cell lysates.

  • Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing nuclear staining.

Product Profile

Product Name p-c-Myc Antibody (Thr 358)
Antibody Type Tags Antibodies
Modification Notes c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Myc proteins are nuclear proteins with relatively short half lives. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. The L-Myc gene has been reported to be amplified and expressed at high level in human small cell lung carcinomas. The presence of three sequence motifs in the c-Myc COOH terminus, including the leucine zipper, the helix-loop-helix and a basic region provided initial evidence for a sequence-specific binding function. A basic region helix-loop-helix leucine zipper motif (bHLH-Zip) protein, designated Max, specifically associates with c-Myc, N-Myc and L-Myc proteins. The Myc-Max complex binds to DNA in a sequence-specific manner under conditions where neither Max nor Myc exhibit appreciable binding. Max can also form heterodimers with at least two additional bHLH-Zip proteins, Mad and Mxi1, and Mad-Max dimers have been shown to repress transcription through interaction with mSin3.

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WBIPIFIHC

recommended for detection of Thr 358 phosphorylated c-Myc of mouse, rat and human origin by WB, IP, IF and IHC(P):
Species Reactivity

HumanMouseRat

Concentration 1mg/ml
Purification Affinity purified

Target Information

Alternative Names
epitope corresponding to phosphorylated Thr 358 of c-Myc of human origin
Tissue Specificity epitope corresponding to phosphorylated Thr 358 of c-Myc of human origin

Database Links

Entrez Gene 4609

Application

  • Application

    Western blot analysis of phosphorylated c-Myc expression in untreated (A) and UV-treated (B) HT-29 whole cell lysates.

  • Application

    Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing nuclear staining.

Application Notes
recommended for detection of Thr 358 phosphorylated c-Myc of mouse, rat and human origin by WB, IP, IF and IHC(P):

Additional Information

Form Liquid
Storage Instructions For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

  • Catalog Number: OM197728
  • Price: $336.00
  • Discount Price
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  • Store: Out of stock
  • Lead time: 4~6 Week
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