Application
Immunohistochemistry staining of HSPA5 in placenta formlin-fixed paraffin-embedded) tissue using HSPA5 Antibody.| Product Name | HSPA5 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | HSPA5, BIP, Heat shock 70 kDa protein 5, MIF2, GRP-78, GRP78 |
| Product description | Grp78, is a 78 kDa glucose-regulated protein, also known as BiP or immunoglobulin heavy chain binding protein, is a stress-response protein which is induced by agents or conditions that adversely affect endoplasmic reticulum (ER) function. This protein is essential for the proper glycosylation, folding and assembly of many membrane bound and secreted proteins. Grp78 is critical for maintenance of cell homeostasis and the prevention of apoptosis. Grp78 protein levels have been shown to be a reliable biomarker of hypoglycermia as well as serving a neuroprotective function in neurons exposed to glutamate and oxidative stress. Grp78 levels are reduced in the brains of Alzheimer's Disease patients and decreased expression of Grp78 is found associated with missense mutations in the human presenilin-1 (PS1) gene. The induction of the Grp78 protein has been associated with the development of drug-resistance to antitumor drugs. |
| Immunogen | A portion of amino acids 550-600 of human GRP78. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| HSPA5 antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 μg/mL, and immunofluorescence starting at 10 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | HSPA5 |
|---|---|
| Alternative Names | HSPA5 BIP Heat shock 70 kDa protein 5 MIF2 GRP-78 GRP78 |
Application
Immunohistochemistry staining of HSPA5 in placenta formlin-fixed paraffin-embedded) tissue using HSPA5 Antibody.| Application Notes | HSPA5 antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 μg/mL, and immunofluorescence starting at 10 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | HSPA5 antibody can be stored short term 4 ˚C. For long term storage aliquot and store at -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.2% gelatin, 0.05% sodium azide. |
Data sheet for OM281429