WB
Western blot analysis using JAK1 antibody against CACO2 (1), PC-12 (2), A431 (3) cell lysate.IHC
Immunohistochemical analysis of paraffin-embedded Human lung cancer tissues using JAK1 antibody with DAB staining.IHC
Immunohistochemical analysis of paraffin-embedded Human ovarian cancer tissues using JAK1 antibody with DAB staining.IHC
Immunohistochemical analysis of paraffin-embedded Human thyroid carcinoma tissues using JAK1 antibody with DAB staining.IHC
Immunohistochemical analysis of paraffin-embedded Human colon cancer tissues using JAK1 antibody with DAB staining.IHC
Immunohistochemical analysis of paraffin-embedded Human rectal cancer tissues using JAK1 antibody with DAB staining.WB
(D) HeLa cells were treated with FMN for 12 h. Whole cell extracts of STAT3 upstream kinase were assessed by western blot.WB
Western blot analysis using JAK1 antibody against Mouse heart(1),Rat stomach(2), Rat serum(3),Rat liver(4) tissue.| Product Name | Anti-JAK1 antibody-poly-HRP |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | poly-HRP |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:200-1:2000 IHC:1:100-1:1000 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | JAK1 |
|---|---|
| Gene Synonyms | JTK3 AIIDE JAK1A JAK1B |
| Gene Full Name | Janus kinase 1 |
| Gene Summary | This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2020] |
| Molecular Weight(MW) | 133 kDa |
| Source | Rabbit |
| Cellular Localization | nucleus,cytoplasm,cytosol,cytoskeleton |
| SwissProt ID | P23458 |
|---|
WB
Western blot analysis using JAK1 antibody against CACO2 (1), PC-12 (2), A431 (3) cell lysate.
IHC
Immunohistochemical analysis of paraffin-embedded Human lung cancer tissues using JAK1 antibody with DAB staining.
IHC
Immunohistochemical analysis of paraffin-embedded Human ovarian cancer tissues using JAK1 antibody with DAB staining.
IHC
Immunohistochemical analysis of paraffin-embedded Human thyroid carcinoma tissues using JAK1 antibody with DAB staining.
IHC
Immunohistochemical analysis of paraffin-embedded Human colon cancer tissues using JAK1 antibody with DAB staining.
IHC
Immunohistochemical analysis of paraffin-embedded Human rectal cancer tissues using JAK1 antibody with DAB staining.
WB
(D) HeLa cells were treated with FMN for 12 h. Whole cell extracts of STAT3 upstream kinase were assessed by western blot.
WB
Western blot analysis using JAK1 antibody against Mouse heart(1),Rat stomach(2), Rat serum(3),Rat liver(4) tissue.| Application Notes | WB:1:200-1:2000 IHC:1:100-1:1000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide. |
