| Gene Symbol |
SDHA
|
| Gene Synonyms |
FP PGL5 SDH1 SDH2 SDHF CMD1GG MC2DN1 NDAXOA |
| Gene Full Name |
succinate dehydrogenase complex flavoprotein subunit A |
| Gene Summary |
This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014] |
| Molecular Weight(MW) |
73 kDa |
| Cellular Localization |
Membrane, Mitochondrion, Mitochondrion inner membrane |