| Gene Symbol |
SGCG
|
| Gene Synonyms |
35DAG 35kDa 5430420E18Rik A4 DAGA4 DMDA DMDA1 gamma-SG LGMD2C LGMDR5 MAM SCARMD2 |
| Gene Full Name |
sarcoglycan gamma |
| Gene Summary |
This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq, Oct 2008] |
| Alternative Names |
35 kDa dystrophin-associated glycoprotein 35DAG 35kD dystrophin-associated glycoprotein sarcoglycan gamma (35kD dystrophin-associated glycoprotein) sarcoglycan gamma (35kDa dystrophin-associated glycoprotein) TYPE |
| Cellular Localization |
Cell membrane, Cytoplasm, Cytoskeleton, Membrane |