| Gene Symbol |
CYP2C9
|
| Gene Synonyms |
CPC9
CYP2C
CYP2C10
CYPIIC9
P450-2C9
P450IIC9 |
| Gene Full Name |
cytochrome P450 family 2 subfamily C member 9 |
| Gene Summary |
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. |
| Molecular Weight(MW) |
56 kDa |
| Cellular Localization |
Endoplasmic reticulum, Membrane, Microsome |
