| Gene Symbol |
SUV39H1
|
| Gene Synonyms |
MG44
KMT1A
SUV39H
H3-K9-HMTase 1 |
| Gene Full Name |
SUV39H1 histone lysine methyltransferase |
| Gene Summary |
This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants. |
| Molecular Weight(MW) |
48 kDa |
| Cellular Localization |
Centromere, Chromosome, Nucleus |
