This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.
Alternative Names
activin A receptor type IB activin A receptor type II-like kinase 4 activin receptor type IB activin receptor-like kinase 4 ACTR-IB ACTRI ACVR1A ACVRLK2 ALK-4 ALK2 FOP Serine/threonine-protein kinase receptor R2 SKR1 TSRI