WB
Western blot analysis using TSC1 antibody against Hela(1) cell lysate.IHC
Immunohistochemical analysis of paraffin-embedded Human prostate cancer tissues using TSC1 antibody with DAB staining.WB
Western blot analysis using TSC1 antibody against Mouse muscle(1) tissue.| Product Name | Anti-TSC1 antibody-HRP |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | HRP |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:200-1:2000 IHC:1:100-1:1000 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | TSC1 |
|---|---|
| Gene Synonyms | LAM TSC Hamartin |
| Gene Full Name | TSC complex subunit 1 |
| Gene Summary | This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signaling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including TSC2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis and lymphangioleiomyomatosis. |
| Molecular Weight(MW) | 130 kDa |
| Cellular Localization | Cytoplasm, Membrane |
| SwissProt ID | Q92574 |
|---|
WB
Western blot analysis using TSC1 antibody against Hela(1) cell lysate.
IHC
Immunohistochemical analysis of paraffin-embedded Human prostate cancer tissues using TSC1 antibody with DAB staining.
WB
Western blot analysis using TSC1 antibody against Mouse muscle(1) tissue.| Application Notes | WB:1:200-1:2000 IHC:1:100-1:1000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide. |
