ICC/IF
Immunofluorescence analysis of T24 cells using BLNK antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin .| Product Name | Anti-BLNK antibody-AF488 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | AF488 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IFFC |
| IF:1:50-1:200 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | BLNK |
|---|---|
| Gene Synonyms | AGM4 BASH Bca BLNK-S Ly-57 LY57 Lyw-57 SLP-65 SLP65 |
| Gene Full Name | B cell linker |
| Gene Summary | This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012] |
| Alternative Names | B cell adaptor containing SH2 domain B-cell activation B-cell adapter containing a SH2 domain protein B-cell adapter containing a Src homology 2 domain protein BCA cytoplasmic adapter protein lymphocyte antigen 57 MGC111051 Src homology 2 domain-containing leukocyte protein of 65 kDa Src homology [SH2] domain-containing leukocyte protein of 65 kD |
| Molecular Weight(MW) | 50KD(observed:39kDa) |
| Cellular Localization | Cell membrane, Cytoplasm, Membrane |
| SwissProt ID | Q8WV28 |
|---|
ICC/IF
Immunofluorescence analysis of T24 cells using BLNK antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin .| Application Notes | IF:1:50-1:200 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide. |
