| Gene Symbol |
CBFA2T3
|
| Gene Synonyms |
ETO2
MTG16
MTGR2
ZMYND4
RUNX1T3 |
| Gene Full Name |
CBFA2/RUNX1 partner transcriptional co-repressor 3 |
| Gene Summary |
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010] |
| Molecular Weight(MW) |
71KD,63KD |
| Cellular Localization |
Golgi apparatus, Membrane, Nucleus |
