WB
Western blot analysis using PPM1A antibody against HepG2(1) cell lysate.IHC
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissues using PPM1A antibody with DAB staining.IHC
Immunohistochemical analysis of paraffin-embedded Human colon cancer tissues using PPM1A antibody with DAB staining.IHC
Immunohistochemical analysis of paraffin-embedded Human Kidney tissues using PPM1A antibody with DAB staining.IHC
Immunohistochemical analysis of paraffin-embedded Human lung cancer tissues using PPM1A antibody with DAB staining.WB
Western blot analysis using PPM1A antibody against Rat stomach tissue(1) .| Product Name | Anti-PPM1A antibody-poly-HRP |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | poly-HRP |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:200-1:2000 IHC:1:100-1:1000 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | PPM1A |
|---|---|
| Gene Synonyms | PP2CA PP2Calpha PP2C-ALPHA |
| Gene Full Name | protein phosphatase, Mg2+/Mn2+ dependent 1A |
| Gene Summary | The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] |
| Molecular Weight(MW) | 42KD，51KD |
| Cellular Localization | Cytoplasm, Membrane, Nucleus |
| SwissProt ID | P35813 |
|---|
WB
Western blot analysis using PPM1A antibody against HepG2(1) cell lysate.
IHC
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissues using PPM1A antibody with DAB staining.
IHC
Immunohistochemical analysis of paraffin-embedded Human colon cancer tissues using PPM1A antibody with DAB staining.
IHC
Immunohistochemical analysis of paraffin-embedded Human Kidney tissues using PPM1A antibody with DAB staining.
IHC
Immunohistochemical analysis of paraffin-embedded Human lung cancer tissues using PPM1A antibody with DAB staining.
WB
Western blot analysis using PPM1A antibody against Rat stomach tissue(1) .| Application Notes | WB:1:200-1:2000 IHC:1:100-1:1000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide. |
