Recombinant full length protein within human Claudin 1.
Conjugation
AF488
Key Feature
Isotype
IgG
Host Species
Rabbit
Tested Applications
IF-P
IF-P:1:200
Species Reactivity
Human
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
CLDN1
Gene Synonyms
CLD1 SEMP1 ILVASC
Gene Full Name
claudin 1
Gene Summary
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008]