This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. This gene has its highest expression in the central nervous system and plays a prominent role in neural tissue development and regulation of adult brain function. Mutations in this gene have been associated with numerous neurological disorders. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]
Alternative Names
FLJ56884 FLJ58356 Fox-1 homolog C
Molecular Weight(MW)
50 kDa(Observed MW: 55 kDa)
Cellular Localization
Cytoplasm,Nucleus.
Application
WB
Western blot analysis of NeuN in mouse brain , rat brain lysates and using NeuN Goat pAb.
IF-P
Immunofluorescence analysis of NeuN(Green) in mouse brain tissue using NeuN Goat pAb, and DAPI(Blue)
Application Notes
WB:1:500-1:1000 IF-P:100-1:300
Additional Information
Form
Liquid
Storage Instructions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Storage Buffer
Liquid in PBS, 50% glycerol, 0.05% Proclin 300, 0.08%BSA.