The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide, and to viruses. This gene has been identified as a target candidate in the treatment of SARS-CoV-2-infected patients to potentially lessen or inhibit a severe inflammatory response. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2020]
Application
FC
FCM analysis of THP-1 cells The black line histogram represents the isotype control, normal mouse IgG2a.
Application Notes
ICC/IF:1:50-1:500 FC:1:50-1:200 WB:1:200-1:2000
Additional Information
Form
Liquid
Storage Instructions
Store at 4° C, **DO NOT FREEZE**. Stable for one year from the date of shipment. Non-hazardous. No MSDS required.
Storage Buffer
Each vial contains 50 µg IgG2a kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin.