This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a smooth muscle actin that is involved in vascular contractility and blood pressure homeostasis. Mutations in this gene cause a variety of vascular diseases, such as thoracic aortic disease, coronary artery disease, stroke, and Moyamoya disease, as well as multisystemic smooth muscle dysfunction syndrome. [provided by RefSeq, Sep 2017]
Molecular Weight(MW)
43 kDa
Cellular Localization
Cytoplasm,Cytoskeleton
Application
WB
Western blot analysis of ACTA2 in mouse heart , rat heart lysates and using ACTA2 Goat pAb.
IF-P
Immunofluorescence analysis of ACTA2(Green) in human Breast cancer tissue using ACTA2 Goat pAb, and DAPI(Blue).
Application Notes
WB:1:500-1:1000 IF-P:100-1:300
Additional Information
Form
Liquid
Storage Instructions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Storage Buffer
Liquid in PBS, 50% glycerol, 0.05% Proclin 300, 0.08%BSA.