This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]
Alternative Names
Gastric inhibitory polypeptide receptor GIPR
Molecular Weight(MW)
54 kDa,49 kDa,50 kDa(Observed band size:54 kDa)
Cellular Localization
Cell membrane,Membrane.
Application
WB
Western Blot.
Positive WB detected in:Hela whole cell lysate, PC-3 whole cell lysate, U251 whole cell lysate, HepG2 whole cell lysate.
All lanes: GIPR antibody at 1:1000.
Secondary
Goat polyclonal to human IgG at 1/50000 dilution.
Application Notes
WB:1:500-1:5000
Additional Information
Form
Liquid
Storage Instructions
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.