| Gene Symbol |
MAP3K12
|
| Gene Synonyms |
DLK
MUK
ZPK
ZPKP1
MEKK12
HP09298 |
| Gene Full Name |
mitogen-activated protein kinase kinase kinase 12 |
| Gene Summary |
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described. |
| Molecular Weight(MW) |
93 kDa |
| Cellular Localization |
Cell membrane, Cytoplasm, Membrane |
