| Gene Symbol |
HLA-G
|
| Gene Synonyms |
MHC-G |
| Gene Full Name |
major histocompatibility complex, class I, G |
| Gene Summary |
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] |
| Molecular Weight(MW) |
38KD |
| Cellular Localization |
Cell membrane, Cell projection, Endoplasmic reticulum, Endosome, Membrane, MHCI, Secreted |
