| Gene Symbol |
GABBR2
|
| Gene Synonyms |
GABR2 HG20 DEE59 GPR51 EIEE59 GPRC3B NDPLHS GABABR2 HRIHFB2099 |
| Gene Full Name |
gamma-aminobutyric acid type B receptor subunit 2 |
| Gene Summary |
The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010] |
| Molecular Weight(MW) |
106kDa |
| Cellular Localization |
Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Lysosome, Nucleus |