| Gene Symbol |
MAP2K5
|
| Gene Synonyms |
MEK5
MAPKK5
PRKMK5
HsT17454 |
| Gene Full Name |
mitogen-activated protein kinase kinase 5 |
| Gene Summary |
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011] |
| Molecular Weight(MW) |
50kDa |
| Cellular Localization |
Spindle, Cytosol, nucleus, cytoplasm. |
