ICC/IF
Immunofluorescence analysis of HUVEC cells using APP antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Product Name | Anti-APP antibody-AF488 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | AF488 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IFFC |
| IF:1:50-1:200 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | APP |
|---|---|
| Gene Synonyms | AAA ABETA ABPP AD1 Adap Ag alpha-sAPP APPI betaApp CTFgamma CVAP E030013M08Rik PN-II PN2 preA4 |
| Gene Full Name | amyloid beta precursor protein |
| Gene Summary | This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014] |
| Alternative Names | ABPP AG Alzheimer disease alzheimer disease amyloid A4 protein homolog alzheimer disease amyloid protein Amyloid amyloid A4 Amyloid b Amyloid beta amyloid beta (A4) precursor protein amyloid beta (A4) precursor protein (peptidase nexin-II Alzheimer disease) amyloid beta A4 protein amyloid beta precursor protein (ABPP) amyloid beta protein amyloid beta protein 695 amyloid beta-protein precursor amyloid precursor protein amyloid protein Amyloid β amyloidogenic glycoprotein appican beta-amyloid A4 beta-amyloid peptide beta-amyloid peptide(1-40) beta-amyloid peptide(1-42) beta-amyloid precursor protein beta-amyloid protein cerebral vascular amyloid peptide CTF gamma CTF-alpha OTTHUMP00000096096 Pan-Abeta peptidase nexin-II PreA4 751 protease nexin II protease nexin-II testicular tissue protein Li 2 |
| Molecular Weight(MW) | 87kDa（observed：85/100kDa) |
| Cellular Localization | Amyloid, Cell membrane, Cell projection, Coated pit, Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Nucleus, Secreted |
| SwissProt ID | P05067 |
|---|
ICC/IF
Immunofluorescence analysis of HUVEC cells using APP antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Application Notes | IF:1:50-1:200 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300. |
