| Gene Symbol |
SSH1
|
| Gene Synonyms |
KIAA1298
SSH1L
SSH1
SSH-1L
hSSH-1L |
| Gene Full Name |
slingshot protein phosphatase 1 |
| Gene Summary |
The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] |
| Molecular Weight(MW) |
116kDa |
| Cellular Localization |
Cell projection, Cytoplasm, Cytoskeleton |
