| Gene Summary |
Enables several functions, including beta-catenin binding activity; dynein complex binding activity; and tau-protein kinase activity. Involved in several processes, including apoptotic signaling pathway; positive regulation of organelle organization; and regulation of macromolecule biosynthetic process. Acts upstream of with a positive effect on autosome genomic imprinting. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; positive regulation of protein metabolic process; and regulation of neuron projection development. Located in several cellular components, including dendritic shaft; growth cone; and neuronal cell body. Part of Wnt signalosome; beta-catenin destruction complex; and ribonucleoprotein complex. Is active in glutamatergic synapse; meiotic spindle; and postsynaptic density. Is expressed in several structures, including alimentary system; genitourinary system; immune system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; oral squamous cell carcinoma; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta). [provided by Alliance of Genome Resources, Apr 2025] |