| Gene Symbol |
COMP
|
| Gene Synonyms |
Cartilage oligomeric matrix MED EDM1 EPD1 PSACH THBS5 |
| Gene Full Name |
cartilage oligomeric matrix protein |
| Gene Summary |
The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2016] |
| Molecular Weight(MW) |
83kDa(observed:70kDa) |
| Source |
Rabbit |
| Cellular Localization |
Secreted, extracellular space, extracellular matrix |