| Gene Symbol |
PLCB1
|
| Gene Synonyms |
3110043I21Rik DEE12 EIEE12 mKIAA0581 Phosphb PI-PLC PLC'1 PLC-154 PLC-beta-1 PLC-I PLC154 Plcb PLCB1A PLCB1B PLCbeta1 RATPHOSPHB |
| Gene Full Name |
phospholipase C beta 1 |
| Gene Summary |
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Alternative Names |
1-phosphatidyl-D-myo-inositol-4 5-bisphosphate inositoltrisphosphohydrolase monophosphatidylinositol phosphodiesterase phosphoinositidase C phosphoinositide phospholipase C phosphoinositide phospholipase C-beta-1 phosphoinositide-specific phospholipase c phospholipase C beta 1 (phosphoinositide-specific) phospholipase C-1 phospholipase C-beta-1a Phospholipase C-beta1 phospholipase C-I PLC-154 PLC-beta-1 PLC-I triphosphoinositide phosphodiesterase |
| Molecular Weight(MW) |
139kDa(observed:125kDa) |
| Source |
Rabbit |
| Cellular Localization |
Nucleus membrane, Cytoplasm |