| Gene Symbol |
TGFBR1
|
| Gene Synonyms |
TGFR1
ALK5
SKR4
TbetaR-I
TGF-beta type I receptor |
| Gene Full Name |
transforming growth factor beta receptor 1 |
| Gene Summary |
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
| Molecular Weight(MW) |
56kDa(observed：40kDa） |
| Source |
Rabbit |
| Cellular Localization |
Cell membrane, Cell junction, tight junction, Cell surface, Membrane raft |
