| Product Name | Anti-p21 antibody-RBITC |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Recombinant protein |
| Conjugation | RBITC |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Mouse |
| Species Reactivity | HumanMouseRat |
| Purification | Affinity purified |
| Gene Symbol | CDKN1A |
|---|---|
| Gene Synonyms | CAP20 CDKI CDKN1 CIP1 MDA-6 mda6 P21 p21CIP1 p21WAF SDI1 WAF1 |
| Gene Full Name | cyclin dependent kinase inhibitor 1A |
| Gene Summary | This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015] |
| Alternative Names | Activating Fragment 1 alternate gene name=WAF1 CDK-interacting protein 1 CDK-interaction protein 1 CDKN1A CDNK1A Cip1) cyclin kinase inhibitor Cyclin-dependent kinase inhibitor 1A (p21 cyclin-dependent kinase inhibitor 1A (p21 Cip1) DNA synthesis inhibitor melanoma differentiation associated protein 6 melanoma differentiation-associated protein OTTHUMP00000016298 p21Cip1/Waf1 putative DNA synthesis inhibitor SLC12A9 Wild type p53 activated fragment 1 (WAF1) wild type p53 activated fragment-1 wild-type p53-activated fragment 1 |
| Molecular Weight(MW) | 21kDa（observed：35、21kDa) |
| Cellular Localization | Cytoplasm,Nucleus. |
| SwissProt ID | P38936 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide. |
