IF-P
Immunohistochemical analysis of paraffin-embedded human Kidney tissues using ACE2 antibody with DAB staining.ICC/IF
Immunofluorescence analysis of C2C12 cells using ACE2 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Product Name | Anti-ACE2 antibody-AF488 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Recombinant protein |
| Conjugation | AF488 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Mouse |
| Species Reactivity | HumanMouseRat |
| Purification | Affinity purified |
| Gene Symbol | ACE2 |
|---|---|
| Gene Synonyms | 2010305L05Rik ACEH |
| Gene Full Name | angiotensin converting enzyme 2 |
| Gene Summary | The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible. [provided by RefSeq, Nov 2020] |
| Alternative Names | ACE 2 ACE-related carboxypeptidase ACE2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 angiotensin I converting enzyme 2 angiotensin-converting enzyme homolog angiotensin-converting enzyme-related carboxypeptidase anigotensin-converting enzyme-related carboxypeptidase dipeptidyl carboxydipeptidases ACE2 metalloprotease MPROT15 peptidyl-dipeptidase A renal angiotensin-converting enzyme 2 sACE2 N-terminally-truncated natural isoform zinc metalloprotease |
| Molecular Weight(MW) | 92kDa、52kDa（observed：55、130kDa） |
| Cellular Localization | Cell membrane, Cell projection, Cytoplasm, Membrane, Secreted. |
| SwissProt ID | Q9BYF1 |
|---|
IF-P
Immunohistochemical analysis of paraffin-embedded human Kidney tissues using ACE2 antibody with DAB staining.
ICC/IF
Immunofluorescence analysis of C2C12 cells using ACE2 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide.Purified antibody in PBS with 0.05% PC300. |
