ICC/IF
Immunofluorescence analysis of Hela cells using PAK1 (S144) + PAK2 (S141) + PAK3 (S154) antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Product Name | Anti-PAK1 (S144) + PAK2 (S141) + PAK3 (S154) antibody-AF488 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | AF488 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IFFC |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | PAK1 |
|---|---|
| Gene Synonyms | ADRB2 p21 activated kinase 1 p65 PAK PAK alpha Pak1 Paka PAKalpha Protein kinase MUK2 |
| Gene Full Name | p21 (RAC1) activated kinase 1 |
| Gene Summary | This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many cancer types, and particularly in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020] |
| Molecular Weight(MW) | 61kDa |
| Source | Rabbit |
| Cellular Localization | Nucleoplasm, Cell membrane, ruffle membrane, Cytoplasm, focal adhesion, invadopodium, Chromosome |
| SwissProt ID | Q13153 |
|---|
ICC/IF
Immunofluorescence analysis of Hela cells using PAK1 (S144) + PAK2 (S141) + PAK3 (S154) antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide. |
