| Gene Symbol |
CAND1
|
| Gene Synonyms |
2310038O07Rik 6330512O03Rik D10Ertd516e mKIAA0829 TIP120 TIP120A Tp120a |
| Gene Full Name |
cullin associated and neddylation dissociated 1 |
| Gene Summary |
This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016] |
| Alternative Names |
cullin associated and neddylation disassociated 1 cullin-associated and neddylation-dissociated protein 1 DKFZp434M1414 FLJ10114 FLJ10929 FLJ38691 FLJ90441 p120 CAND1 TBP-interacting protein TBP-interacting protein 120A TBP-interacting protein of 120 kDa A TBP-interacting protein TIP120A |
| Molecular Weight(MW) |
136kDa |
| Source |
Rabbit |
| Cellular Localization |
Nucleus,Cytoplasm |