This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Alternative Names
adhesion molecule fasciclin I-like Fasciclin-I like MGC119510 MGC119511 OSF 2 osteoblast specific factor 2 osteoblast specific factor 2 (fasciclin I-like) osteoblast-specific factor 2 periodontal ligament-specific periostin periostin osteoblast specific factor periostin-like factor PLF POSTN osteoblast-specific factor RP11 412K4.1 RP11-412K4.1