late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Gene Summary
Enables GTPase binding activity and protein-membrane adaptor activity. Contributes to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including cholesterol homeostasis; positive regulation of TORC1 signaling; and regulation of cholesterol transport. Located in lysosome. Part of FNIP-folliculin RagC/D GAP. Is active in Ragulator complex and lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2025]
Alternative Names
FLJ20625 late endosomal/lysosomal adaptor and MAPK and MTOR activator 1 lipid raft adaptor protein p18 p27kip1 releasing factor from RhoA p27Kip1-releasing factor from RhoA p27RF Rho p27RF-Rho protein associated with DRMs and endosomes ragulator complex protein PDRO RhoA activator C11orf59 RhoA activator C11orf59 homolog