ICC/IF
Immunofluorescence analysis of Hela cells using Cathepsin L/V/K/H antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.IF-P
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissues using Cathepsin L/V/K/H antibody with DAB staining.IF-P
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissues using Cathepsin L/V/K/H antibody with DAB staining.| Product Name | Anti-Cathepsin L/V/K/H antibody-AF488 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | AF488 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | CTSL/CTSV/CTSK/CTSH |
|---|---|
| Gene Synonyms | Cathepsin CTSL CTSV CTSK CTSH |
| Gene Full Name | cathepsin L/cathepsin V/cathepsin K/cathepsin H |
| Gene Summary | The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell. [provided by RefSeq, Aug 2020]/The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011]/The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]/The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] |
| Alternative Names | Cathepsin L antibody cathepsin L 1 b antibody Cathepsin L1 antibody Cathepsin L1 light chain antibody CathepsinL antibody CATL antibody CATL1_HUMAN antibody cb15 antibody CTSL antibody CTSL1 antibody |
| Molecular Weight(MW) | 37kDa |
| Source | Rabbit |
| Cellular Localization | Cell membrane, Cytoplasmic vesicle, Lysosome, Membrane, Nucleus, Secreted |
| SwissProt ID | P07711/O60911/P43235/P09668 |
|---|
ICC/IF
Immunofluorescence analysis of Hela cells using Cathepsin L/V/K/H antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.
IF-P
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissues using Cathepsin L/V/K/H antibody with DAB staining.
IF-P
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissues using Cathepsin L/V/K/H antibody with DAB staining.| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
