| Product Name | Anti-PDHA1 antibody-RBITC |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | RBITC |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | PDHA1 |
|---|---|
| Gene Synonyms | E1alpha PDHA Pdha-1 PDHAD PDHCE1A PHE1A |
| Gene Full Name | pyruvate dehydrogenase E1 subunit alpha 1 |
| Gene Summary | The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010] |
| Alternative Names | dehydrogenase PDHE1-A type I pyruvate dehydrogenase pyruvate dehydrogenase (lipoamide) alpha 1 pyruvate dehydrogenase alpha 1 pyruvate dehydrogenase alpha subunit precursor (EC 1.2.4.1) pyruvate dehydrogenase complex pyruvate dehydrogenase complex E1-alpha polypeptide 1 pyruvate dehydrogenase E1 alpha 1 pyruvate dehydrogenase E1 alpha 1 subunit pyruvate dehydrogenase E1 component alpha subunit pyruvate dehydrogenase E1-alpha precursor pyruvate dehydrogenase E1alpha subunit |
| Molecular Weight(MW) | 43kDa |
| Source | Rabbit |
| Cellular Localization | Mitochondrion matrix |
| SwissProt ID | P08559 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
