| Gene Symbol |
PPIA
|
| Gene Synonyms |
Cphn CYCA CyP-18 CyP-A CYPA CYPH HEL-S-69p I79_011869 p1B15 p31 SP18 |
| Gene Full Name |
peptidylprolyl isomerase A |
| Gene Summary |
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008] |
| Alternative Names |
cyclophilin Cyclophilin A Cyclosporin A-binding protein CyP A EC 5.2.1.8 epididymis secretory sperm binding protein Li 69p HGNC:9253 MGC117158 MGC12404 MGC23397 Peptidyl-prolyl cis-trans isomerase A peptidylprolyl isomerase A (cyclophilin A) PPIA PPIase PPIase A rotamase Rotamase A T cell cyclophilin |
| Molecular Weight(MW) |
18kDa |
| Source |
Rabbit |
| Cellular Localization |
Cytoplasm, Nucleus, Secreted |