ICC/IF
Immunofluorescence analysis of C2C12 cells using PTRF/CAVIN1 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Product Name | Anti-PTRF/CAVIN1 antibody-AF488 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | AF488 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | CAVIN1 |
|---|---|
| Gene Synonyms | 2310075E07Rik Cav-p60 CAVIN cavin-1 CGL4 FKSG13 PTRF |
| Gene Full Name | caveolae associated protein 1 |
| Gene Summary | This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009] |
| Alternative Names | cav-p60 cavin cavin-1 congenital generalized lipodystrophy 4 FLJ90031 polymerase I and transcript release factor RNA polymerase I and transcript release factor TTF-I interacting peptide 12 |
| Molecular Weight(MW) | 43kDa(observed：55kDa) |
| Source | Rabbit |
| Cellular Localization | Cell membrane,Microsome,Endoplasmic reticulum,Cytoplasm>Cytosol,Mitochondrion,Nucleus |
| SwissProt ID | Q6NZI2 |
|---|
ICC/IF
Immunofluorescence analysis of C2C12 cells using PTRF/CAVIN1 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
