| Gene Symbol |
RBFOX1
|
| Gene Synonyms |
2BP1 A2bp A2BP1 FOX-1 FOX1 HRNBP1 |
| Gene Full Name |
RNA binding fox-1 homolog 1 |
| Gene Summary |
The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] |
| Alternative Names |
A FOX-1 A2BP1 ataxin 2 binding protein 1 ataxin 2-binding protein 1 fox-1 homolog A fox-1-like RNA-binding protein 1 hexaribonucleotide binding protein 1 hexaribonucleotide-binding protein 1 RNA binding protein fox-1 homolog 1 RNA-binding protein |
| Molecular Weight(MW) |
43kDa(observed:53kDa) |
| Source |
Rabbit |
| Cellular Localization |
Cytoplasm, Nucleus |