| Gene Symbol |
SYN2
|
| Gene Synonyms |
2900074L19Rik EPILX EPILX1 MRX50 Syn-1 Syn1-S SYN1a SYN1b SYNI SYNII |
| Gene Full Name |
synapsin II |
| Gene Summary |
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. Polymorphisms in this gene are associated with abnormal presynaptic function and related neuronal disorders, including autism, epilepsy, bipolar disorder and schizophrenia. Alternative splicing of this gene results in multiple transcript variants. The tissue inhibitor of metalloproteinase 4 gene is located within an intron of this gene and is transcribed in the opposite direction. [provided by RefSeq, Feb 2014] |
| Alternative Names |
brain protein 4.1 C-terminal truncated due to the introduction of a pre-mature stop codon by the inclusion of intron 8 synapsin Ib synaptic vesicle protein |
| Molecular Weight(MW) |
63kDa |
| Source |
Rabbit |
| Cellular Localization |
Synapse, Golgi apparatus, Presynapse, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle |