| Product Name | Anti-HLA-ABC (MHC I) antibody-RBITC |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | RBITC |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | HLA-A |
|---|---|
| Gene Synonyms | HLAA |
| Gene Full Name | major histocompatibility complex, class I, A |
| Gene Summary | HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen so that they can be recognized by cytotoxic T cells. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. More than 6000 HLA-A alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the malaria parasite, the human immunodeficiency virus (HIV), and the severe acute respiratory syndrome coronavirus (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population.[provided by RefSeq, Aug 2020] |
| Alternative Names | cell surface glycoprotein integral membrane protein heavy chain HLA class I histocompatibility antigen A-1 alpha chain HLA protein allele A25 HLA-A HLA-A 2402 HLA-A*0201 alpha chain human leukocyte antigen HLA-A*0204 HLA-A*0207 alpha chain human leukocyte antigen HLA-A-0102 allele HLA-A24AK HLA-A25 human leukocyte antigen leukocyte antigen class I-A major histocompatibility complex class I A MHC class I antigen HLA-A heavy chain MHC HLA-A cell surface antigen MHC HLA-A10-alpha-2 chain precursor MHC HLA-A2.4a chain MHC HLA-A24 cell surface glycoprotein |
| Molecular Weight(MW) | 41kDa |
| Source | Rabbit |
| Cellular Localization | Cell membrane, Endoplasmic reticulum membrane |
| SwissProt ID | P04439 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
